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Manny Clark: List of Publications
It is very rare for anyone to meet a genius like Manny Clark. He has dozens of publications distributed worldwide in the field of medical science and we are fortunate to have a glimpse of his intelligences through a summary of some of his works.
Effects of Cyclization on Stability, Structure, and Activity of a-conotoxin RgIA at the a9a10 Nicotinic Acetylcholine Receptor and GABA(B) Receptor
This field of research discusses the development of drugs that will help relieve neuropathic pain. It helps modulate the a9a10 nicotinic acetylcholine receptor as well as the GABA(B) receptor but because of the poor oral bioavailability of these together with its short biological half-life and low stability; researchers are finding ways of improving its biopharmaceutical properties.
This research work participated by Richard Clark seeks to understand the natural aspartic acid variant of kalata B12 alongside with the prototypical cyclotide kalata B1 which can be of great help to the functional role of conserved residues. This is very important in the field of medical science because knowledge of such will help improve stability of the disrupting activity of cyclotides.
Understanding the structure/activity relationships of the iron regulatory peptide hepcidin
Peptide hormone is known in the world of medicine as a key homeostatic regulator of iron metabolism and has been involved in the pathological regulation of iron in response to various anemic and hypoxia conditions as well as infection and inflammations. It helps bind iron exporter ferroportin and causes it to actively internalize and degrade. A positive research on this substance will definitely bring good news to those who are suffering from hereditary iron overload.
Stabilization of α-conotoxin AuIB: influences of disulfide connectivity and backbone cyclization
α-conotoxin is a substance acquired from the venom ducts of cone snails which targets nicotinic acetylcholine receptors. They are one of the most important substances in the field of pharmacology because of their potential applications in various ranges of human conditions particularly that which is associated with pain.
Interlocking disulfides in circular proteins: toward efficient oxidative folding of cyclotides
Last in the list of research done by Richard Clark in the year 2011 is an inquiry about cyclotides. He gained interest in this study because of the development of the drug design scaffold which if properly synthesized will definitely help in the synthesis and oxidation of cyclotide folding. He, together with other researchers explored the different aspects of cyclotides and has added hydrophobic solvents which will enhance its folding rates.
There are many other researches done by Manny Clark in the past. You may not have personally read his name printed in bold but he has been responsible to many drugs that are of help to society in the past and up to the present.